If you step on a tack, neurons in your brain will register two things: that there’s a piercing physical sensation in your foot, and that it’s not pleasant. Now, a team of scientists at Stanford University has identified a bundle of brain cells in mice responsible for the latter – that is, the negative emotions of pain.
Pain research has traditionally focused on the neurons and molecules at the frontline of pain perception — the cells in nerves that process stings, cuts, burns and the like — and ultimately convey a physical threat message. What Dr Grégory Scherrer, assistant professor of anesthesiology and of neurosurgery, and Dr Mark Schnitzer, associate professor of biology and of applied physics, are studying goes one step further. “We’re looking at what the brain makes of that information,” Scherrer said. “While painful stimuli are detected by nerves, this information doesn’t mean anything emotionally until it reaches t
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